Vukovar-Srijem county is Croatia’s easternmost county. It is known for it’s geographical location and recent history. The county borders Bosnia and Herzegovina and Serbia, and is made out of five cities (Vukovar, Vinkovci, Županja, Otok, Ilok) and twenty six municipalities. During the last thirty years, Vukovar-Srijem county has been affected by misfortunes, from war devastations in 1991. to recession in 2009. The consequences are still visible today, which is primarily shown by the demographic structure of the population. Looking on the main demographic factors (natural demographic trends, sex and age structure, the migration population balance and educational structure), it is noticed that the county is characterized by depopulation, that is, population ageing, sex and age structure in the shape of an urn, negative migration population balance and below-average educational structure. When it comes to the economic development of the county, there are also noticed some negative trends. Falling GDP and rising unemployment. A special challenge for the whole country, especially for underdeveloped counties such as Vukovar-Srijem, is SARS-CoV-2 epidemic which again caused a drop in GDP and an increase in unemployment. Although, real consequences of the epidemic will be visible in 2021. In accordance with the above, the aim of this paper is to propose certain measures that will have a positive impact on the demographic structure of the population, and such measures will have a positive effect on economic indicators.