Ankylosing spondylitis is a chronic inflammatory rheumatic disease that begins gradually. This condition, with an unknown etiology, is believed to have a significant genetic role in the development of the disease. It has been observed that it occurs three times more often in men than in women. The main feature of the disease is an inflammatory process that occurs at the point of attachment of the joint capsule, tendon and ligament to the bone, and is called entensitis. Inflammatory processes begin to appear in the area of the sacroiliac joints and continue to spread proximally, ascending, affecting the spine and costovertebral joints, and later the shoulders and hips. Diagnosing ankylosing spondylitis can be challenging at first. Early recognition is key to initiating potential therapies. Once the diagnosis is made, treatment begins. Physiotherapy plays a significant role in the treatment of ankylosing spondylitis. At the beginning of the physiotherapy process, it is necessary to make an adequate assessment of the patient and then start with physiotherapy interventions. The goal of physiotherapy interventions is to reduce pain, stiffness and fatigue, improve chest mobility, lost movement and function, and strengthen muscles and maintain proper posture. Physiotherapy intervention includes breathing exercises, strengthening exercises, stretching exercises, mobilization techniques, physical therapy and the PNF (proprioceptive neuromuscular facilitation) method. Emphasis is placed on the importance of maintaining physical function.