Carpal tunnel syndrome is a common neuropathy caused by compression of the median nerve inside the carpal tunnel in the wrist. Assessment of the patient's condition, planning of therapy, application of various therapeutic modalities and evaluation of the achieved results are key factors in the treatment of this syndrome. The pathophysiology of carpal tunnel syndrome encompasses the mechanisms that lead to nerve compression and the resulting symptoms. Etiological factors are varied, including repetitive motions, improper work habits, and certain medical conditions. Risk groups that are more susceptible to the development of this syndrome have been identified, which is crucial for targeted prevention. The clinical picture includes pain, tingling, weakness and loss of function in the affected arm. The physiotherapy process begins with a detailed assessment of the patient, including history and physical examination. Therapy planning is based on an individualized approach, with goals aimed at reducing symptoms, improving functionality and preventing relapse. Evaluation of the therapeutic effect is essential for adjusting the treatment and ensuring optimal results. Preventive measures and advice for patients are also very important to reduce the risk of recurrence of the syndrome.