Amputation of an extremity can be considered in three main contexts: emergency amputation, planned amputation, and the decision not to perform amputation. Emergency amputation, often performed due to severe sepsis or trauma, does not allow for detailed preparation. In contrast, planned amputation involves a multidisciplinary team and preoperative rehabilitation to prepare the patient for surgery and recovery. Preoperative phase involves educating the patient about post-amputation procedures, conducting a physical therapy evaluation, and implementing prehabilitation. Postoperative phase lasts approximately 10-14 days and focuses on postoperative care, monitoring wound healing, managing pain, preventing contractures and edema, and early verticalization of the patient. Pre-prosthetic phase begins once the wound has healed and is aimed at preparing the residual limb for the prosthesis. This phase includes conditioning the patient, improving circulation, strength, and range of motion, and preventing contractures. Prosthetic phase focuses on the selection, fabrication, and application of prostheses, as well as rehabilitation and learning to walk with the prosthesis.