Muscular dystrophy describes a very heterogeneous group of hereditary and progressive groups of neuromuscular diseases, and there cause is in gene mutations that also has an important role in development and maintenance of muscle function. Duchenne muscular dystrophy is the most common muscular dystrophy in children characterized by mutation genes for the protein dystrophin on the X chromosome. Dystrophin is a subsarcolemmal protein that is bound by the trans-membrane complex to laminin in the cytosol and connects cytoskeleton and the extracellular matrix and allows contraction of the muscle fiber. In X-linked recessive inheritance the altered gene is carried on one of the X chromosomes to help determine the gender of the child. The transition phase in Duchenne muscular dystrophy is a period of significant muscular weakness and atrophy with consequent functional impairments, striking adjustments in posture, and increasing difficulty in walking. This phase begins between the ages of 6 and 12. The emphasis in kinesitherapy in the treatment of muscle weakness in the transitional phase of muscular dystrophy is to maintain the strength of the proximal muscles of the limbs with exercises to strengthen the muscles of the trunk, and the exercises of stretching and strengthening of the muscles of the distal parts of the limbs. Concurrent prevention or therapy of contractures and respiratory physiotherapy are also necessary. Adequate and timely application of orthoses and other orthopedic aids contribute to the longer independence. Proper nutrition is important for every child, and especially for children with muscular dystrophy. The parents and the patient are the main ones in rehabilitation. No treatment can be successful without patient commitment and parental support.