The topic of this paper is small and medium-sized enterprises in Vukovar-Srijem County. Small and medium-sized enterprises influence technological development, reduce regional disparities, increase employment of local population, etc., and thus represent a strong driver of the economy. The main problems of small and medium-sized enterprises in the Republic of Croatia are the small number of companies with a long tradition of doing business, the negative influence of politics, the low cooperation between the business and the research sector and the lack of sources of co-financing of business projects. Such obstacles in the business of small and medium-sized enterprises often mean the end of their business; therefore, it is the key to identify such obstacles and work on removing them. Access to finance is defined by companies as a key obstacle to their further development. The small and medium-sized enterprises of the Vukovar-Srijem County, due to the poor economic situation within the county, have a very high closing rate, which was also affected by the recent economic crisis. Developing an entrepreneurial climate, investment and structural funds of the European Union, the incentive funds of the Republic of Croatia and credit subsidies are the key solutions needed to stimulate entrepreneurship growth. The results of such support measures are already visible in the number of companies that have achieved economic growth after receiving subsidies and grants, nevertheless many years of investments in such projects are required to bring about economic growth in the Republic of Croatia and thus in the Vukovar-Srijem County.