By extending life expectancy, osteoporosis is becoming a growing problem in many developed countries of the world. The most common is metabolic bone disease, which, along with associated diseases and complications, represents a great social, economic and personal burden. The basis of the disease consists in the deterioration of bone tissue due to the loss of calcium from the bones, which results in the fragility and fragility of the bones. Lack of calcium and phosphorus intake, reduced physical activity, poor living habits, are just some of the factors that contribute to the development of osteoporosis. There are several chronic diseases that affect bone metabolism resulting in increased bone remodeling and poor bone mass quality. The most pronounced influence on the incidence of osteoporosis have thyroid disease, diabetes, kidney disease, Cushing's syndrome and inflammatory bowel disease. Osteoporosis is characterized by high prevalence, incidence of bone fractures, and high treatment costs. Treatment of osteoporosis begins with an effective public health action to raise public awareness of the importance of the disease and the possibilities of avoiding risk factors for its occurrence. Adequate intake of calcium and vitamin D along with physical therapy, rehabilitation, physical activity in combination with drugs are the basis of success in the treatment of osteoporosis. The aim of this paper is to show the impact of thyroid disease and diabetes on the development of osteoporosis, and to show ways to treat and prevent osteoporosis.