Systemic sclerosis or systemic scleroderma is a connective tissue disease. The disease is characterized by thickening of the skin and involvement of internal organs. It is divided into: systemic scleroderma (divided into: diffuse and limited form) and localized scleroderma (divided into: morphea and linear scleroderma). It is manifested by general and skin symptoms, vascular changes and also affects the internal organs. The disease is initially most visible on the skin of the hands and face, and over time the whole body becomes sclerosed, like an armor. The cure for scleroderma is unknown, so early diagnosis is essential. Based on the SOAP method, an individual therapy plan is developed for the patient. Physical therapy in addition to drug therapy plays a very important role in the treatment of patients. In addition to conducting physiotherapy procedures and physiotherapy exercises, it is important to emphasize myofascial therapy, which is one of the modern forms of manual therapy for patients with scleroderma, as well as conducting education. The main goal of treatment is relief of symptoms, improvement of function, prevention and control of complications. Systemic scleroderma has a high mortality rate especially in patients with early diffuse disease and poor prognostic signs such as extensive skin involvement and internal organ involvement.