Manual therapy is a part of the procedure in rehabilitation process in which the improvement of the patient's condition is achieved through the application of the therapist's hand. Dating back to ancient times it continues to play a significant role in current health care. Manual techniques include various forms of massage, soft and nerve tissue mobilization, joint mobilization and manipulation, visceral mobilization used by a manual therapist in the process of prevention, diagnosis and treatment of soft tissues and other joint structures to reduce pain, increase range of motion, reduce or eliminate inflammation soft tissue, induced relaxation, improved soft tissue recovery, improved stability, facilitated movement, and improved function. It is often the most important part of physical therapy. Different concepts named after the authors who applied them today define the approach and manner of conducting manual therapies. All of these techniques require additional therapist education, excellent perception, and a wealth of experience. A wide range of different techniques allows you to customize the treatment for each individual. The wider the therapist’s range of knowledge, the more effective he or she is in the outcome of treatment, depending on the problem and the desired effects. This is because a certain technique is better for a certain specific pathology. The manual therapist must have knowledge of pathology, biomechanics, ergonomics, applied anatomy and physiology, movement analysis, therapeutic diagnostics, performance of techniques, practice and psychosocial factors that affect the outcomes of therapy and its effectiveness. This techniques can be very successfull in treating various diseases and injuries. The aim of this paper is to present various ways and principles of performing manual techniques and to investigate their impact on the musculoskeletal system.