It has been proven that the type II diabetes is the most common form of diabetes mellitus. 90% to 95% of people with diabetes who are over the age of 20 have type II diabetes. Type II diabetes also has several different names: insulin-independent diabetes and older age onset diabetes. Current therapeutic options for type II diabetes include: lifestyle changes, oral hypoglycemic drugs (OHL) and insulin. Traditional diet and physical activity with education about self-control and self-management are considered as the basic therapeutic principle that is introduced as soon as an elevated glycemic level is established. Type II diabetes with genetic factors also has numerous other factors such as obesity, physical inactivity and insulin resistance. Because of these factors it is possible to prevent type II diabetes, which can be achieved with preventive health measures. Physical activity affects regulation of hypertension, reduced body mass, increased energy consuption, improves insulin sensitivity, and lowers glucose level in blood. The goal of this paper is to highlight the importance of preventing type II diabetes and to explore the benefitial effects of physical activity and exercise in development of diabetes. Main goal is to determine whether type II diabetes can be prevented with physical activity and in which way can that be achieved.