PTSD is a complex disease that belongs to adjustment disorders and the influence of difficult stressors like accidents, wars, childhood trauma, domestic violence, and community violence, psychic and physical violence, rape, and it leaves permanent consequences on an individual whose quality of life is meaningly downgraded. The accent is put on the correct diagnosis, on establishing comorbidity existence, and the right treatment that should be integrated with medicaments therapy, and well-designed therapy insight with exercises that help the person to control their emotions, behavior, and thoughts. When differentiating PTSD diagnoses from symptomatically similar diagnoses, it has to be put in mind that there are some comorbidities of PTSD. The most common comorbidities are depression disorders, anxiety disorders, schizophrenia, alcoholism, and many else. PTSD treatment does not have a unified approach in therapy choosing and pharmaceutic interventions, so most of the therapy methods are considered efficient to the same extent. By that, PTSD therapy aspects are divided into educations, psychotherapy, and psychosocial support, and psychofarmacotherapy.