Changes in blood pressure and heart rate caused by the conduct of physical activity are the subject of numerous studies. The aim of this study was to determine the changes in blood pressure and heart rate values that occur after the winter break, that is, during the preparatory period and the spring season in the players of the football club "NK Croatia" from Bogdanovci. The sample consisted of 20 male footballers with an average age of 24. The variables measured were blood pressure, heart rate and VO2max was calculated with the help of the Cooper test at the beginning and end of the preparatory period. Measurements were carried out on 3 occasions: at the beginning of the preparatory period, at the end of the preparatory period (i.e. the beginning of the competitive season) and at the end of the competitive season. In addition to measurements, at the beginning of the study, the subjects completed a questionnaire with data on the years of life and length of training, the position of play. The results showed that there was no statistically significant difference in measured values among players playing in different positions. A statistically significant difference was found in the values of systolic pressure between the second and third measurements, and results showed decrease in systolic pressure. VO2max value increased between the initial measurement and the end of the preparatory period. Based on these results, we can conclude that football training has a positive effect on the cardiovascular system and the overall health of the athlete.