Amputation is a complex process in which an interdisciplinary team participates, and it includes the planning and implementation of the amputation and the rehabilitation of the patient. Any amputation should aim to have a well-formed and functionally capable stump so that prosthetic provision can be carried out later. Rehabilitation should help the patient to accept a new lifestyle, adapt it to physical deficiencies and help form new lifestyle habits. After surgery, people have an increased risk of deformations in the locomotor system, and therefore muscle atrophy should be prevented. Rehabilitation is carried out in five phases: 1. pre-operative phase, 2. postoperative phase, 3. pre-prosthetic phase, 4. prosthetic phase, 5. long-term follow-up phase. The physiotherapist has an important role in rehabilitation. With the help of physiotherapy interventions, before the actual amputation, the patient should be taught and prepared how to walk with crutches, learn exercises to examine the complications of long-term lying down and strengthen the musculature. After the amputation, he should be helped to apply what he has learned and help with new difficulties. After amputation, a phantom sensation and phantom pain will often appear, which can be a disturbing factor in rehabilitation, but over time the pain will decrease and will appear less and less. The mental state of the patient is also a very important factor in rehabilitation, because amputation is considered a dramatic life event, which requires great mental strength. For this reason, psychological support and conversation should be provided immediately after the operation.