Overuse injuries of the musculoskeletal system usually occur in people who deal with sports but also in people who perform their daily activities by performing regular movements, overuse injuries may occur in all people regardless of the age group. Overuse is one of the most common etiologic factors that lead to injuries. They occur slowly, overstressing certain tissues of the locomotor system and causing microtraumas. There are different causes that may lead to overuse injuries, but it is necessary to recognize each of them in time to initiate proper treatment and to avoid further complications. Overuse syndrome as consequence have pathological anatomic changes on the tendon and well as on their joints of bone, muscle, cartilage, and peripheral nerves. Most people, in the beginning, ignore the first syndromes of overuse injuries and continue with the activities makes things even worse for the condition, and in most cases, they react only when their pain prevent them for doing exercise and pain then begins to occur while resting. The mode of this discussion is usually limited to the analysis of different individual painful syndromes, specific localization of the painful syndrome in the musculoskeletal system, or the specific tissues affected by overuse injuries. The diagnosis is made by taking a medical history, clinical examination (clinical tests) and with the help of radiological methods. Each treatment is individually and requires a multidisciplinary team that ensures effective teamwork and quality communication both with the patient and with the family. One of the goals of future research should be to focus on the prevention or early intervention and what is more important, patient education about prevention and the importance of exercise in preventing recurrence.