Schizophrenia is a serious mental illness that leads to severe disorders of social, business, and family functioning. The symptoms vary in severity and intensity throughout various phases of the disease. The treatment of schizophrenia is a long and demanding process for both the patient and his family. During the treatment, a number of pharmacological and psychotherapeutic interventions are performed, and the family usually has the most important role, carrying a great burden and responsibility, while at the same time also being endangered by the very presence of the disease. Schizophrenia brings difficulties in all family relationships, both between parents and children, as well as between spouses. The everyday life of a schizophrenic patient is filled with numerous functional disorders and carries certain problems in all fields. Therefore, psychoeducation is the basis for the treatment of schizophrenia patients and the patient's family. The most important guidelines for family members dealing with this extremely severe mental illness are reducing harmful factors, working on self-esteem and maintaining life skills, while also finding the time for their own interests and pleasures during the fight against the disease.