Developmental disorders are inborn or acquired conditions of an organism that by their nature require a certain professional approach in order to enable expression and development of abilities that are to be preserved and, in doing so, a better life quality. The slower speech diagnosis refers to the lag during the time until 3 or 4 years of age when the speech is still in development. Autism spectrum disorder (ASD) is a neurodevelopment disorder that is apparent through social interaction, social communication and language deviations, but also some present, limited and recurring behavioral and habitual features. Cerebral palsy represents a clinical entity that marks a congregation of non-progressive, but very often mutable motor disorders that are a repercussion of developmental disorder or a brain damage that occurred in an early development stage. For the purposes of clinical medicine, the quality of life refers to an illness, its treatment and functional condition of the diseased in its environment. The purpose of this paper is to present the life quality of children with developmental disabilities and to determine the influence of physical and occupational therapy on the improvment of the quality of life.